Oprah Winfrey, one of the most powerful, successful and influential women in the world, spoke during the Democratic National Convention program Wednesday night, lending her voice and support to Vice President Kamala Harris’ presidential bid.Winfrey spoke during the lead-up to Minnesota Gov. Tim Walz’s acceptance of the Democratic vice presidential nomination. She quoted civil rights icon, the late Rep. John Lewis, saying he "knew very well how far this country has come because he was one of the brilliant Americans who helped to get us where we are.”"But he also knew that the work is not done,” Winfrey said. “The work will never be done because freedom isn’t free.” Winfrey, a registered independent, also made a direct appeal to unaffiliated and undecided voters to back Harris, saying, “Decency and respect are on the ballot in 2024.” She adds: “Character and values matter most of all.”Winfrey closed with a resounding shout of “Let us choose Kamala Harris!” The DNC is quickly becoming the hottest ticket in Chicago, with an appearance last night from Lil Jon, and performances from Stevie Wonder, John Legend, Maren Morris and Pink to close out the week.In 2020, Winfrey supported President Joe Biden and Vice President Kamala Harris, celebrating Harris as the first woman and the first woman of color to serve as VP.“I was thinking the other day, ‘I wish Maya were alive to see it,’ ” Winfrey said to People Magazine in 2020. “…There’s no way to measure what the election of Kamala Harris means for all women, all colors, everywhere.”Winfrey is no stranger to politics. Her endorsement of former President Barack Obama in 2008 made headlines worldwide. She endorsed Hillary Clinton in 2016 but largely stayed off the trail. The Associated Press contributed to this story.