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Iowa State took full advantage of its opportunity. The Cyclones are now 6-0 overall and 3-0 in Big 12 play after a big win at West Virginia.Iowa State vs. West Virginia score updates, highlights and statsHere's how the Cyclones won Saturday night.Final: Iowa State 28, West Virginia 16 Iowa State is 6-0 for the second time in program history. The Cyclones outscored West Virginia 28-9 over the final three quarters and put up nearly 400 yards of total offense in the win.The defense stood strong after the opening drive, forcing two turnovers and shutting down the WVU rushing attack.Cyclones get onside kickWVU's last-ditch onside attempt went out of bounds, so Iowa State will take over and should be able to run out the clock.West Virginia scores in the final momentsThat'll make the score look a bit closer, but this game is just about done.Jaheim White caught a pass from 10 yards out to score. The WVU 2-point attempt was no good, so it's a 12-point game with 1:10 to go.West Virginia scoring drive: 11 plays, 67 yards, 3:25Carson Hansen scores third touchdown to ice the gameThat should do it.Iowa State now leads by 18 points with 4:42 to go after Carson Hansen's third score of the day. He's up to 96 rushing yards on 20 carries.Iowa State scoring drive: 10 plays, 33 yards, 6:43Jontez Williams picks off Garrett GreeneThe Cyclone defense has West Virginia rattled.A tipped pass fell to Jontez Williams, and he intercepted it in West Virginia territory. It's ISU ball, leading by 11, with 11:25 to go.Carson Hansen extends the lead with another touchdownA huge defensive holding in the end zone gave Iowa State new life, and Carson Hansen took advantage. He ran it in from 3 yards out to extend the lead to 21-10.Iowa State is 11:57 away from improving to 6-0.Iowa State scoring drive: 10 plays, 65 yards, 5:03End of third quarter: Iowa State 14, West Virginia 10Two big plays to wide receiver Eli Green put Iowa State deep in WVU territory. First, Green caught a 12-yard pass to convert a third down. Then on the very next play, Becht found Green again for 34 yards down the sideline.Iowa State will be at the West Virginia 17-yard line, leading 14-10, when the fourth quarter gets underway.Jamison Patton picks off Garrett GreeneSafety Jamison Patton was waiting back in coverage and read the overthrow from Garrett Greene and picked it off.That ends West Virginia's drive after it got into ISU territory.Iowa State has it at its own 35 after the pick from the Des Moines native. It's Patton's second career pick.Iowa State punts it right backNothing doing for Iowa State on that drive. The Cyclones did move the ball close to midfield, but a third-and-8 pass felt incomplete.It'll be West Virginia ball at its own 14-yard line after the punt. There's 5:21 on the clock in the third quarter.Iowa State defense gets off the fieldA bad snap pushed West Virginia back on second-and-5, and the Mountaineers couldn't make up for it on third down. Iowa State has the ball back at its own 12-yard line after a punt.It's still 14-10, Iowa State, with 9:10 left on the third quarter.Cyclones forced to punt on first drive of second halfA third down pass to Benjamin Brahmer was broken up, and Iowa State is forced to punt.West Virginia has it at its own 24-yard line following Tyler Perkins' 42-yard boot.Halftime: Iowa State 14, West Virginia 10Iowa State lined up for a Hail Mary pass to the end the half, but the West Virginia pass rush got to Becht.Still, Iowa State leads 14-10 and will receive the second-half kickoff. After allowing a long touchdown drive on the game's opening possession, that's a good outcome for the Cyclones.ISU holds a 222-188 edge in offensive yardage. Both teams have picked up 13 first downs. Jayden Higgins and Jaylin Noel have combined for 143 receiving yards.West Virginia trims lead with field goalThe Mountaineers were stuffed on third down, but they did enough to get into field goal range. Michael Hayes II drilled the 43-yard field goal attempt to make it 14-10 Iowa State with 32 seconds left in the half.Iowa State has two timeouts remaining. Remember, Iowa State gets the ball to start the second half as well.West Virginia honors Rocco Becht's dad, Anthony BechtA cool moment in Morgantown, as Anthony Becht, a former West Virginia star and longtime NFL tight end, was celebrated on the field during the game. He was inducted into the West Virginia Hall of Fame earlier this year.Iowa State takes the lead with Carson Hansen touchdown rushIowa State has its first lead of the game, courtesy of an 11-yard run from Carson Hansen.The Cyclones ate up more than half of the second quarter on that drive. West Virginia will get the ball back with 2:39 to go.Iowa State scoring drive: 17 plays, 91 yards, 8:08Dylan Barrett down with injuryA starting Iowa State offensive lineman is down with an apparent injury. We'll keep an eye on his status the rest of the night.Cyclone defense gets key stopIowa State did allow a third-and-long conversion, but the defense did its job on the next set of downs, pushing WVU back and forcing a punt.Iowa State has it at its own 9-yard line after a punt. It's tied 7-7 with 10:47 on the clock in the second quarter.Cyclones respond with Jaylin Noel touchdownA Jaylin Noel catch-and-run for 60 yards down the middle of the field winds up in the end zone, and we have a tie ballgame, less than a minute after the missed field goal.Iowa State scoring drive: 3 plays, 80 yards, 0:58West Virginia misses field goalAfter a third down conversion was overturned on review and found to be an incomplete pass, West Virginia missed a 36-yard field goal that would've made it 10-0.Iowa State takes over at its own 18-yard line, still trailing by a touchdown.End of first quarter: West Virginia 7, Iowa State 0A very quick first quarter is in the books. Each team had just one possession, with West Virginia on the field for its second drive.The two teams have combined for just one incomplete pass on nine total attempts, so there haven't been many clock stoppages. West Virginia's run game has been effective, tallying 76 yards on 15 carries.Jacob Ellis back inThe ISU linebacker has returned to the game.Iowa State's first drive comes up empty after missed field goalIowa State's opening drive started in a great way, with a 37-yard pass downfield to Jayden Higgins. The Cyclones picked up another first down to move into field goal range, but Kyle Konrardy's 47-yard kick hooked left.West Virginia takes over at its own 29, holding a 7-0 lead.West Virginia takes the early leadA long drive featuring mostly runs winds up in the end zone.Jaheim White took the carry 8 yards to the left side for a score to cap the drive. West Virginia ran it 11 times and threw 3 times, gained 6 first downs, and now leads 7-0.West Virginia scoring drive: 14 plays, 75 yards, 7:42Jacob Ellis hurt for Iowa StateIowa State's Jacob Ellis is down and being tended to by the training staff.ISU's already depleted linebacker corps can't afford to lose more key contributors.West Virginia receives firstIowa State's defense will see the field first.How to watch Iowa State vs. West VirginiaWhen: 7 p.m. CT, Saturday, Oct. 12Where: Milan Puskar Stadium, Morgantown, West VirginiaTV: FOXLivestream: Fox Sports Live (TV provider log-in required)Online radio: The Varsity NetworkWest Virginia vs. Iowa State football series historyIowa State and West Virginia have met 11 times, all since the Mountaineers joined the Big 12 Conference just over a decade ago. The two teams played annually from 2012-22 before that streak ended last season.West Virginia holds a 6-5 lead, but Iowa State has held the recent advantage. The Cyclones are 4-1 in the last five meetings. Morgantown has been a mixed bag for Iowa State.In 2019, true freshman running back Breece Hall burst onto the scene with 132 rushing yards and three touchdowns in a win at West Virginia, nearly doubling his total yardage from the first four games of that season.But West Virginia defended its home turf well the next time, defeating Iowa State, 38-31, in 2021.West Virginia vs. Iowa State odds, betting lineIowa State is a 3.5-point favorite at West Virginia, according to FanDuel Sportsbook. The over/under is set at 51.5 points.What to know about West VirginiaThe Mountaineers are 2-0 in Big 12 play and 3-2 overall.West Virginia will likely try to lean on its running game — three different Mountaineers have already run for at least 295 yards, led by CJ Donaldson at 361 and five touchdowns. Dual-threat quarterback Garrett Greene has run for 295 yards and three scores while passing for 1,061 yards.He has a 7-to-4 touchdown-to-interception ratio, with a 4-to-4 ratio over the team's past three games. West Virginia is 3-0 when Greene rushes for a touchdown and 0-2 when he doesn't reach the end zone.The Mountaineers won a big road game last week, beating Oklahoma State 38-14. They ran for 389 yards and four touchdowns on 65 rushes while only attempting 16 passes.Iowa State ranked 11th in latest AP pollIowa State has moved up to No. 11 this week (tied with Notre Dame) after the 5-0 start. The Cyclones jumped five spots from the previous poll.